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Na superfície dos comprimidos em forma de losango,
é permitida a aplicação do logotipo da empresa "ZT" de um
lado e da dosagem "50" ou "100" do outro.
Comprimidos revestidos, de cor azul a azul-clara com tons perlados, de modo arredondada (doses de 25 mg, 50 mg ou 100
mg) ou em maneira de losango (doses de 50 mg ou cem mg), com
superfície convexa. Depois da administração oral única de sildenafila em dose de
100 mg, a concentração plasmática máxima média de sildenafila é de
por volta de 440 ng/ml (com coeficiente de alteração de 40%).
Como a ligação da sildenafila e de seu principal metabólito N-desmetil ao plasma é de 96%, a concentração plasmática máxima
média de sildenafila livre é de mais um menos
18 ng/ml (38 nM). A biodisponibilidade absoluta
média após a administração oral é de 41% (com modificação de 25% a 63%).
Na faixa de doses recomendada (de 25 a cem mg), os parâmetros AUC
e Cmax da sildenafila aumentam proporcionalmente à dose. A hipotensão sintomática geralmente acontece dentro de
quatro horas depois da administração da sildenafila.
A administração concomitante da sildenafila e do bloqueador alfa-adrenérgico pode conduzir ao desenvolvimento de hipotensão sintomática em alguns pacientes predispostos. |
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